Nisoldipine D4
| Product Name | Nisoldipine D4 |
|---|---|
| Alternate Names | Nisoldipine Stable Isotopes, Stable Isotopes of Nisoldipine |
| CAT No. | CS-O-02771 |
| CAS No. | 1219795-47-7 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 392.4 g/mol |
| Mol. For. | C20H20D4N2O6 |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Nisoldipine |
| Purity | Not less than 90 % |
| Smileys | O=C(C(C(C(C([2H])=C1[2H])=C(C([2H])=C1[2H])[N](=O)=O)C(C(OC)=O)=C(C)N2)=C2C)OCC(C)C |
| Canonical Smiles | CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
| InchIKey | VKQFCGNPDRICFG-YKVCKAMESA-N |
| Inchl | InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3/i6D,7D,8D,9D |
| IUPAC | 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2,3,4,5-tetradeuterio-6-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Nisoldipine D4 is a deuterated version of the calcium channel blocker, Nisoldipine. It is commonly used in research studies to determine the pharmacokinetics and metabolism of Nisoldipine in vivo and in vitro. Deuterium labeling is a common technique used in drug development to improve the pharmacokinetics and drug metabolism of a compound.
Nisoldipine D4 is a dihydropyridine calcium channel blocker that works by inhibiting the influx of calcium ions into the smooth muscle cells of blood vessels, resulting in vasodilation and reduced blood pressure. It is primarily used in the treatment of hypertension, angina pectoris, and Raynaud's phenomenon.
The chemical structure of Nisoldipine D4 is C20H20D4N2O6, and it has a molecular weight of 412.48 g/mol. The compound is soluble in ethanol, methanol, and dimethyl sulfoxide (DMSO) but is insoluble in water. Nisoldipine D4 is a white to off-white crystalline powder that is stable under normal storage conditions.
The pharmacokinetics of Nisoldipine D4 have been extensively studied, and it has been found to have similar pharmacokinetic properties to Nisoldipine. However, the deuterium labeling of Nisoldipine D4 has been shown to improve the bioavailability, half-life, and clearance of the drug. This makes it a promising candidate for the development of improved versions of Nisoldipine for the treatment of hypertension and other cardiovascular diseases.
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Related Compounds
Dehydro Nisoldipine-d7 | Nisoldipine D6 |