2-hydroxy Desipramine D3, also known as 2-hydroxy desmethylimipramine D3, is a stable isotope-labeled compound that is commonly used in research and clinical studies as an internal standard or reference material for the quantification of desipramine and its metabolites in biological samples.
Desipramine is a tricyclic antidepressant that works by increasing the levels of norepinephrine in the brain, which helps to elevate mood and reduce symptoms of depression. 2-hydroxy Desipramine D3 is a metabolite of desipramine that is formed in the liver and excreted in urine.
The chemical formula of 2-hydroxy Desipramine D3 is C18H18D3ClN2O, and it has a molecular weight of 307.83 g/mol. It is a white to off-white crystalline powder that is soluble in organic solvents like methanol, ethanol, and acetonitrile.
The usage of 2-hydroxy Desipramine D3 is mainly focused on pharmacokinetic and pharmacodynamic studies, where it is used to determine the metabolism, bioavailability, and elimination of desipramine in humans and animals. It is also used as a calibration standard in analytical methods like liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of desipramine and its metabolites in biological fluids.
Overall, 2-hydroxy Desipramine D3 is a valuable tool in the field of pharmacology and toxicology, as it enables accurate and precise measurement of desipramine and its metabolites, which is critical for understanding the safety and efficacy of these drugs.