N-Desbutyl Lumefantrine D9
| Product Name | N-Desbutyl Lumefantrine D9 |
|---|---|
| Alternate Names | Lumefantrine Stable Isotopes, Stable Isotopes of Lumefantrine |
| CAT No. | CS-O-02989 |
| CAS No. | 1346606-35-6 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 481.89 g/mol |
| Mol. For. | C₂₆H₁₅D₉Cl₃NO |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Lumefantrine |
| Smileys | CCCCNCC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O |
| Canonical Smiles | CCCCNCC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O |
| InchIKey | YLBUTQNEBVPTES-HVYWULERSA-N |
| Inchl | InChI=1S/C26H24Cl3NO/c1-2-3-10-30-15-25(31)24-14-19(29)13-23-21(11-16-4-6-17(27)7-5-16)22-12-18(28)8-9-20(22)26(23)24/h4-9,11-14,25,30-31H,2-3,10,15H2,1H3/b21-11-/i1D3,2D2,3D2,10D2 |
| IUPAC | 1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]-2-(1,1,2,2,3,3,4,4,4-nonadeuteriobutylamino)ethanol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
N-Desbutyl Lumefantrine D9 is a deuterated derivative of the anti-malarial drug, Lumefantrine. Lumefantrine is a synthetic aryl amino alcohol that is used in combination with Artemether to treat uncomplicated malaria caused by Plasmodium falciparum. N-Desbutyl Lumefantrine D9 is an isotopically labeled form of the drug that is used in pharmacokinetic studies to determine the metabolic fate of Lumefantrine in the body.
The chemical structure of N-Desbutyl Lumefantrine D9 contains nine deuterium atoms that are substituted for hydrogen atoms at specific positions in the molecule. This isotopic labeling allows scientists to track the drug's absorption, distribution, metabolism, and excretion in the body using mass spectrometry.
N-Desbutyl Lumefantrine D9 is typically administered orally in tablet form and is rapidly absorbed into the bloodstream. It is metabolized in the liver by the cytochrome P450 enzyme system to form several metabolites, including the active metabolite, desbutyl-Lumefantrine. The drug has a half-life of approximately four to six days and is eliminated from the body primarily through fecal excretion.
In summary, N-Desbutyl Lumefantrine D9 is a valuable tool in pharmacokinetic research and drug development. Its isotopic labeling provides important information on the metabolic fate of Lumefantrine, which can help researchers optimize drug dosing and improve treatment outcomes for malaria patients.
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Related Compounds
Lumefantrine D18 | Lumefantrine D9 |