Product Name |
7-Ethyl-10-hydroxycamptothecin-d5 (SN 38-D5) |
Alternate Names |
Camptothecin Stable Isotopes, Stable Isotopes of Camptothecin |
CAT No. |
CS-O-03147
|
CAS No. |
718612-51-2 |
Category |
Stable Isotopes |
Stock |
IN-Stock
|
Mol. Wt. |
397.44 g/mol |
Mol. For. |
C₂₂H₁₅D₅N₂O₅
|
Hazardous |
This is a Hazardous Compound
|
COA |
View Sample COA
|
MSDS |
View Sample MSDS
|
Parent API |
Camptothecin |
Purity |
Not less than 90 % |
Smileys |
OC1=CC=C2C(C(C([2H])([2H])C([2H])([2H])[2H])=C(CN3C4=CC([C@@]5(O)CC)=C(COC5=O)C3=O)C4=N2)=C1 |
Controlled |
No |
Shipping |
Free for purchase above 1000$ |
Delivery |
In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
Return |
Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
Ordering |
Place your order online or by email sales@clearsynth.com |
If you find a better price anywhere else we guarantee Price match.
7-Ethyl-10-hydroxycamptothecin-d5 (SN 38-D5) is a deuterated derivative of the active metabolite of irinotecan (CPT-11), a chemotherapeutic agent used to treat various types of cancers. SN 38-D5 is labeled with five deuterium atoms, which make it useful for pharmacokinetic studies and drug metabolism research.
SN 38-D5 is a topoisomerase I inhibitor, which means that it interferes with the function of the enzyme responsible for unwinding and re-ligating DNA during replication. By preventing DNA replication, SN 38-D5 can damage and kill cancer cells. SN 38-D5 is particularly effective against solid tumors, including colorectal, lung, and ovarian cancers.
SN 38-D5 is typically administered intravenously, either alone or in combination with other chemotherapeutic agents. The dosage and frequency of administration depend on the type and stage of cancer being treated, as well as the patient’s overall health and response to treatment.
Like other chemotherapeutic agents, SN 38-D5 can cause a range of side effects, including nausea, vomiting, diarrhea, fatigue, and hair loss. Patients receiving SN 38-D5 may also experience a decrease in white blood cell count, which can increase the risk of infection.
In conclusion, SN 38-D5 is a valuable tool in cancer research and treatment. Its unique isotopic labeling allows for precise pharmacokinetic studies, while its potent topoisomerase I inhibition makes it an effective chemotherapy agent against solid tumors. However, the potential side effects of SN 38-D5 highlight the need for careful patient monitoring and management during treatment.