Hydrochlorothiazide 13C6

Hydrochlorothiazide 13C6 is a medication that belongs to the thiazide diuretic drug class. It is used to treat high blood pressure and fluid retention caused by various medical conditions such as congestive heart failure, kidney problems, and liver cirrhosis. Hydrochlorothiazide 13C6 works by helping the kidneys eliminate excess salt and water from the body, which in turn reduces blood volume and lowers blood pressure. This medication is usually taken orally once per day, with or without food, as directed by a healthcare provider. Chemically, Hydrochlorothiazide 13C6 is a sulfonamide derivative consisting of a benzothiadiazine ring with a chlorine atom and a sulfonamide group attached. The 13C6 labeling indicates that six carbon atoms in the molecule are replaced with their heavier isotope, carbon-13. This labeling technique is often used in pharmacokinetic studies to track the fate of a drug in the body and determine its metabolic pathways. Hydrochlorothiazide 13C6 is metabolized in the liver, and its metabolites are excreted in the urine. The elimination half-life of this drug is approximately 6-15 hours, depending on the individual's kidney function and other factors. Like all medications, Hydrochlorothiazide 13C6 may cause side effects such as dizziness, headache, nausea, and electrolyte imbalances. It is important to follow the dosage and usage instructions provided by a healthcare professional and report any adverse effects promptly.