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Fidaxomicin D7

Chemical Name Fidaxomicin D7
CAT No. CS-O-03624
CAS Registry# 2143934-06-7
Status Prompt Dispatch
Category Stable Isotopes
Mol. Wt. 1065.08 g/mol
Mol. For. C₅₂H₆₇D₇Cl₂O₁₈
Hazardous This is a Hazardous Compound
COA View Sample COA

Additional Information

Controlled No
Parent API Fidaxomicin
Therapeutic Antibiotics
Isotopic Enrichment Not less than 95%
Smileys O=C(C(C(O)=C(Cl)C(O)=C1Cl)=C1CC)O[C@H]([C@H](O[C@H]2OC/C(C(O[C@](C/C=C3C)([H])[C@H](O)C)=O)=C\C=C\C[C@](/C(C)=C\[C@H](CC)[C@@H](O[C@](OC(C)(C)[C@H](OC(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@H]4O)([H])[C@@H]4O)\C(C)=C/3)([H])O)C)[C@@H]([C@@H]2OC匀䰀
Canonical Smiles CCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C
Inchl InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
IUPAC [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate
Hazardous Yes

Usage and description

Fidaxomicin D7 is a derivative of the antibiotic Fidaxomicin, which is used for the treatment of Clostridium difficile-associated diarrhea (CDAD). It is a macrocyclic antibiotic that selectively targets the RNA polymerase of C. difficile, which is responsible for the replication of the bacterium. Fidaxomicin D7 is a deuterated form of Fidaxomicin, which means that seven of its hydrogen atoms have been replaced by deuterium atoms. This modification enhances the drug's stability and prolongs its half-life, allowing for less frequent dosing. The chemical structure of Fidaxomicin D7 consists of a macrocycle with a unique spiroketal moiety, which is responsible for its potent antibacterial activity. The drug is administered orally and is rapidly absorbed in the intestine. It is metabolized in the liver and excreted primarily in the feces, with a small portion being eliminated in the urine. Fidaxomicin D7 is highly effective in the treatment of CDAD, with a cure rate of up to 90%. It has also been shown to have a lower rate of recurrence compared to other antibiotics used for CDAD. However, it is important to note that Fidaxomicin D7 is a prescription-only drug and should only be used under the guidance of a healthcare professional. Additionally, it is important to follow the prescribed dosing regimen and complete the full course of treatment to ensure maximum effectiveness and minimize the development of antibiotic resistance.

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