Aprepitant D4
| Chemical Name | Aprepitant D4 |
|---|---|
| Alternate Names | Aprepitant Stable Isotopes, Stable Isotopes of Aprepitant |
| CAT No. | CS-O-06411 |
| CAS Registry# | 1133387-60-6 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 538.45 g/mol |
| Mol. For. | C₂₃H₁₇D₄F₇N₄O₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Aprepitant |
| Purity | 95% |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | O=C1NC(CN(CCO2)[C@@H](C(C([2H])=C3[2H])=C(C([2H])=C3F)[2H])[C@H]2O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)=NN1 |
| Canonical Smiles | CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F |
| InchIKey | ATALOFNDEOCMKK-NSVJKUEGSA-N |
| Inchl | InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1/i2D,3D,4D,5D |
| IUPAC | 3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Aprepitant D4 is a deuterated form of Aprepitant, which is a neurokinin-1 (NK1) receptor antagonist used in the prevention of chemotherapy-induced nausea and vomiting. It is a selective antagonist of the NK1 receptor, which plays a crucial role in the emetic response to chemotherapy. Aprepitant D4 is used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy.
The chemical formula of Aprepitant D4 is C23H22D4F6N4O, and its molecular weight is 494.51 g/mol. It is a white to off-white crystalline powder that is insoluble in water but soluble in methanol and ethanol. The deuterated form of Aprepitant is used in pharmacokinetic studies to determine the metabolic pathways of the drug and its active metabolites.
Aprepitant D4 is metabolized primarily by CYP3A4 and is excreted in the feces and urine. It has a half-life of approximately 12 hours and reaches maximum plasma concentrations within 3 hours of oral administration. The recommended dosage of Aprepitant D4 varies depending on the type of chemotherapy and the patient's medical history.
In conclusion, Aprepitant D4 is a useful tool in pharmacokinetic research and is commonly used in combination with other antiemetic agents for the prevention of chemotherapy-induced nausea and vomiting. Its selective antagonism of the NK1 receptor makes it an effective treatment option for patients undergoing highly emetogenic chemotherapy.
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Related Compounds
Aprepitant benzyl intermediate D4 | rac-Aprepitant-D4 | Fosaprepitant D4 | Aprepitant intermediate D4 | Fosaprepitant D4 Dimeglumine | Aprepitant-13C2,d2 (Major) | Fosaprepitant dimeglumine 13C6 |