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Chlorthalidone D4

Chemical Name Chlorthalidone D4
CAT No. CS-O-06484
CAS Registry# 1794941-44-8
Status Prompt Dispatch
Category Stable Isotopes
Mol. Wt. 342.79 g/mol
Mol. For. C₁₄H₇D₄ClN₂O₄S
Hazardous This is a Hazardous Compound
COA View Sample COA

Additional Information


Controlled No
Parent API Chlorthalidone
Therapeutic Anti-Hypertensives
Isotopic Enrichment Not less than 95%
Smileys OC(NC1=O)(C2=CC([S](N)(=O)=O)=C(Cl)C=C2)C(C1=C3[2H])=C(C([2H])=C3[2H])[2H]
Canonical Smiles C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O
InchIKey JIVPVXMEBJLZRO-RHQRLBAQSA-N
Inchl InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)/i1D,2D,3D,4D
IUPAC 2-chloro-5-(4,5,6,7-tetradeuterio-1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
Hazardous Yes


Usage and description


Chlorthalidone D4 is a deuterated form of chlorthalidone, which is a diuretic medication used to treat hypertension, congestive heart failure, and kidney disease. It works by increasing urine production, which helps to reduce excess salt and water in the body, thereby lowering blood pressure and decreasing the workload on the heart. Chlorthalidone D4 is chemically identical to chlorthalidone, but with four of its hydrogen atoms replaced by deuterium atoms. This makes it useful in pharmacokinetic studies, where researchers can use it to track the drug's metabolism and distribution in the body. It is also used in forensic toxicology to identify the presence of chlorthalidone in biological samples. The recommended dose of chlorthalidone D4 varies depending on the individual's condition, but typically ranges from 12.5 to 50 mg per day. It is usually taken orally once a day, preferably in the morning to avoid interrupting sleep with frequent urination. Like chlorthalidone, chlorthalidone D4 can cause side effects such as dizziness, headache, nausea, and electrolyte imbalances. It may also interact with other medications, so it is important to inform the prescribing doctor of any other drugs being taken. Chlorthalidone D4 should not be used during pregnancy or breastfeeding.

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