Dasatinib D8
| Product Name | Dasatinib D8 |
|---|---|
| Alternate Names | Dasatinib Stable Isotopes, Stable Isotopes of Dasatinib |
| CAT No. | CS-O-06532 |
| CAS No. | 1132093-70-9 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 496.05 g/mol |
| Mol. For. | C₂₂H₁₈D₈ClN₇O₂S |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Dasatinib |
| Purity | 95% |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | CC1=NC(NC2=NC=C(C(NC(C(Cl)=CC=C3)=C3C)=O)S2)=CC(N4C([2H])([2H])C([2H])([2H])N(CCO)C([2H])([2H])C4([2H])[2H])=N1 |
| Canonical Smiles | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO |
| InchIKey | ZBNZXTGUTAYRHI-COMRDEPKSA-N |
| Inchl | InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)/i6D2,7D2,8D2,9D2 |
| IUPAC | N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-[2,2,3,3,5,5,6,6-octadeuterio-4-(2-hydroxyethyl)piperazin-1-yl]pyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Dasatinib D8 is a deuterated version of the drug Dasatinib, which is a potent tyrosine kinase inhibitor used to treat certain types of cancers such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is a small molecule inhibitor that targets the BCR-ABL fusion protein, which is responsible for the overproduction of white blood cells in CML patients. In addition, it also targets other tyrosine kinases such as c-KIT, SRC family kinases, and PDGFR, which are involved in the development and progression of various types of cancers.
Dasatinib D8 is used as an internal standard in mass spectrometry-based quantitative analysis of Dasatinib and its metabolites in biological samples. Deuterium labeling of Dasatinib D8 provides several advantages over the unlabeled drug, including improved sensitivity, accuracy, and precision in mass spectrometry analysis. It also helps to distinguish the drug from endogenous compounds present in the sample, thereby reducing the risk of false positives or false negatives.
Chemically, Dasatinib D8 is a white to off-white powder that is soluble in dimethyl sulfoxide (DMSO) and methanol. Its molecular formula is C22H18D8N7O2S with a molecular weight of 488.64 g/mol. The drug is stable under normal conditions and should be stored at -20°C in a dry and dark place. Its use and handling should be done only by trained professionals who have experience with handling hazardous chemicals.
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Related Compounds
Deschloro Dasatinib-d7 | Dasatinib D8 N-Oxide | Dasatinib-d4 | Dasatinib-13C415N2 |