Haloperidol-D4[Fluorophenyl-d4]

Haloperidol D4 is a deuterated form of the antipsychotic drug haloperidol. It is commonly used in clinical research studies as a stable isotope-labeled internal standard for quantification of haloperidol in biological samples. The deuterated form allows for improved accuracy and precision in mass spectrometry-based analytical techniques. Haloperidol D4 has the same chemical structure as haloperidol, with the exception of four of its hydrogen atoms being replaced with deuterium atoms. It is a potent dopamine D2 receptor antagonist, meaning it blocks or reduces dopamine activity in the brain. This property makes haloperidol D4 effective in treating various psychiatric disorders, including schizophrenia and bipolar disorder. Haloperidol D4 is typically administered orally or intramuscularly and has a relatively long half-life of around 14-26 hours. It is metabolized in the liver and excreted in urine and feces. Adverse effects of haloperidol D4 include drowsiness, dizziness, extrapyramidal symptoms, and tardive dyskinesia. Overall, Haloperidol D4 is an important tool in pharmacological research, allowing for accurate and precise quantification of haloperidol levels in biological samples. Its chemical properties and therapeutic effects make it a valuable medication for treating psychiatric disorders.