Levofloxacin D8

Levofloxacin D8 is a deuterated derivative of Levofloxacin, which is a third-generation fluoroquinolone antibiotic used to treat a wide range of bacterial infections. Levofloxacin D8 is labeled as an internal standard for quantification of Levofloxacin in biological matrices such as plasma, serum, and urine samples. It is used in various clinical research and pharmacological studies to determine the pharmacokinetics, metabolism, and excretion of Levofloxacin in the body. The chemical formula of Levofloxacin D8 is C18H18D8FN3O4, and its molecular weight is 411.49 g/mol. It is a white to slightly yellow crystalline powder that is soluble in water and organic solvents like methanol, ethanol, and dimethyl sulfoxide (DMSO). The deuterium-labeled compound is stable under normal storage conditions and does not undergo any significant degradation or hydrolysis. Levofloxacin D8 exhibits similar pharmacological properties as Levofloxacin, with a broad spectrum of activity against gram-positive and gram-negative bacteria. It works by inhibiting the bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication and cell division. Levofloxacin D8 has a longer half-life than Levofloxacin, which makes it suitable for use as an internal standard in pharmacokinetic studies. In conclusion, Levofloxacin D8 is a useful tool for researchers and scientists working in the field of clinical pharmacology and drug development. Its stable, deuterium-labeled structure makes it an ideal internal standard for quantification of Levofloxacin in biological matrices, enabling accurate and precise measurements of drug concentrations in various samples.