Lisofylline D7

Lisofylline D7, also known as [7-methyl-D7]-3-isobutyl-1-methylxanthine-6-carboxylic acid, is a deuterated form of Lisofylline, a synthetic compound that has been studied for its anti-inflammatory and immunomodulatory effects. Lisofylline D7 is labeled with seven deuterium atoms, which are stable isotopes of hydrogen, making it a useful tool in pharmacokinetic and pharmacodynamic studies. Lisofylline D7 has been shown to inhibit the production of pro-inflammatory cytokines and chemokines, such as TNF-α, IL-1β, and MCP-1, by modulating transcription factors like NF-κB and AP-1. It also enhances the production of anti-inflammatory cytokines like IL-10, which helps to balance the immune response. Additionally, Lisofylline D7 has been found to reduce oxidative stress and apoptosis, potentially making it a useful therapy for various inflammatory diseases. In terms of usage, Lisofylline D7 is commonly used as a stable isotope-labeled internal standard in mass spectrometry-based pharmacokinetic studies. It can also be used as a reference material for analytical method development and validation. Its chemical formula is C12H11D7N4O4, with a molecular weight of 295.31 g/mol. In conclusion, Lisofylline D7 is a deuterated derivative of Lisofylline that has anti-inflammatory and immunomodulatory effects. Its stable isotope-labeled structure makes it a valuable tool for pharmacokinetic and pharmacodynamic studies, and it may hold potential for the treatment of inflammatory diseases.