Naproxen 13CD3

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation in conditions such as arthritis, menstrual cramps, and other types of pain. It is available in various formulations, including tablets, capsules, and oral suspension. The chemical formula of naproxen is C14H14O3, and its molecular weight is 230.26 g/mol. Naproxen 13CD3 is an isotopically labeled form of naproxen, where three hydrogen atoms are replaced with the stable isotope carbon-13. This labeling allows for the compound to be used in pharmacokinetic studies, where the drug's absorption, distribution, metabolism, and excretion can be tracked using mass spectrometry. The mechanism of action for naproxen involves inhibition of the cyclooxygenase (COX) enzyme, which is responsible for the production of prostaglandins. Prostaglandins are involved in the inflammatory response, and their inhibition by naproxen leads to a reduction in pain and inflammation. Naproxen 13CD3 has a similar pharmacological profile to naproxen, with the added benefit of being able to track the drug's fate in the body. It has a half-life of approximately 14 hours and is metabolized in the liver before being excreted in the urine. In conclusion, Naproxen 13CD3 is a useful tool for pharmacokinetic studies of naproxen, a commonly used NSAID for pain and inflammation. Its labeling with carbon-13 allows for tracking of the drug's fate in the body using mass spectrometry, providing valuable information for drug development and dosing regimens.