Colchicine D3

Colchicine D3 is a deuterated form of colchicine, a naturally occurring compound found in the autumn crocus plant. This compound is commonly used as a medication for the treatment of gout and familial Mediterranean fever. It works by binding to tubulin, a protein critical for cell division, and inhibiting its polymerization, thus preventing the formation of microtubules. This leads to the suppression of neutrophil activity, which is responsible for the inflammation and pain associated with gout attacks. Colchicine D3 is a stable isotope-labeled compound, which means that it contains three deuterium atoms instead of hydrogen atoms. This provides a useful tool for researchers to study the pharmacokinetics and metabolism of colchicine in vivo, as well as to verify the identity and purity of colchicine in analytical methods. The chemical formula of Colchicine D3 is C22H25D3NO6, with a molecular weight of 419.50 g/mol. It is a white to off-white crystalline powder, soluble in methanol, ethanol, and dimethyl sulfoxide. The compound is stable under normal conditions but should be stored in a cool, dry place away from light and moisture. In summary, Colchicine D3 is a valuable tool for research and a potent medication for the treatment of gout and familial Mediterranean fever. Its deuterated form provides an additional level of precision and accuracy in analytical methods and pharmacokinetic studies.