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Sofosbuvir D6
| Chemical Name | Sofosbuvir D6 |
|---|---|
| CAT No. | CS-O-10984 |
| CAS No. | 1868135-06-1 |
| Status | Available for Immediate Dispatch |
| Category | Stable Isotopes |
| Mol. Wt. | 535.49 mol/g |
| Mol. For. | C₂₂H₂₃D₆FN₃O₉P |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
Additional Information
| Packing | Product will be supplied in Vials, in certain conditions we also use 'Septa Vials' |
|---|---|
| Controlled | No |
| Parent API | Sofosbuvir |
| Purity | Not less than 90% |
| Therapeutic | Antiretroviral / Anti-HIV |
| Isotopic Enrichment | Not less than 95% |
| Smileys | C[C@@]1([C@H](N(C=CC2=O)C(N2)=O)O[C@H](CO[P](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)[C@H]1O)F |
| Canonical Smiles | CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 |
| InchIKey | TTZHDVOVKQGIBA-FMYNZQRGSA-N |
| Inchl | InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1/i1D3,2D3 |
| IUPAC | 1,1,1,3,3,3-hexadeuteriopropan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate |
| Hazardous | Yes |
Usage and description
Sofosbuvir D6 is a deuterated analog of Sofosbuvir, a direct-acting antiviral drug used to treat hepatitis C virus (HCV) infection. The deuterium substitution provides improved pharmacokinetic properties, allowing for better absorption and distribution of the drug in the body. Sofosbuvir D6 works by inhibiting the RNA polymerase enzyme, which is essential for HCV replication, thus preventing the virus from reproducing and spreading in the body.
Sofosbuvir D6 is typically administered orally in the form of a tablet, with a recommended dosage of 400mg per day. The drug is commonly used in combination with other antiviral medications, such as ledipasvir or velpatasvir, to increase its effectiveness in treating HCV infection. Sofosbuvir D6 has been shown to have a high cure rate for HCV, with minimal side effects.
Chemically, Sofosbuvir D6 is a prodrug that is metabolized in the liver to its active form, GS-461203. The drug is primarily eliminated through the kidneys, and its half-life in the body is approximately 0.5 to 2 hours. Sofosbuvir D6 is a white to off-white powder that is soluble in water and ethanol.
In conclusion, Sofosbuvir D6 is an effective and safe medication used to treat HCV infection. Its deuterated structure provides improved pharmacokinetic properties, allowing for better absorption and distribution in the body. When used in combination with other antiviral medications, Sofosbuvir D6 has a high cure rate for HCV, making it an important tool in the fight against this disease.
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