(R)-Ofloxacin-d3

(R)-Ofloxacin-d3 is a deuterated form of the antibiotic drug Ofloxacin. It is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections, including urinary tract infections, respiratory infections, and skin infections. The deuterium substitution in (R)-Ofloxacin-d3 makes it useful for research purposes, particularly in pharmacokinetic studies, as it can be used as an internal standard in mass spectrometry analysis. Chemically, (R)-Ofloxacin-d3 is a synthetic fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, an essential enzyme involved in the replication and repair of DNA. It achieves this by binding to the DNA gyrase enzyme, preventing it from functioning correctly and ultimately leading to the death of the bacteria. The deuterium substitution in (R)-Ofloxacin-d3 does not affect its mechanism of action but can impact the rate of metabolism and elimination from the body. (R)-Ofloxacin-d3 is typically administered orally in the form of tablets or capsules. The recommended dosage and length of treatment depend on the type and severity of the infection being treated, as well as the patient’s age and overall health. Common side effects of (R)-Ofloxacin-d3 include nausea, diarrhea, headache, and dizziness. It is important to note that fluoroquinolone antibiotics have been associated with rare but severe side effects, including tendon damage and nerve damage, and should be used with caution. Overall, (R)-Ofloxacin-d3 is a valuable tool in the treatment and research of bacterial infections.