(15R)-Bimatoprost Acid D4

(15R)-Bimatoprost Acid D4 is a deuterated form of Bimatoprost, which is a synthetic prostamide analog used for the treatment of glaucoma and ocular hypertension. It is a potent agonist of the prostamide receptors and reduces intraocular pressure by increasing the outflow of aqueous humor through the trabecular meshwork and uveoscleral pathways. The deuterated form of Bimatoprost is used in pharmacokinetic studies to determine its metabolic fate in vivo. The presence of deuterium atoms in the molecule allows for tracking of the drug and its metabolites using mass spectrometry. This helps in understanding the pharmacokinetic profile of the drug and its interactions with various enzymes and transporters. Chemically, (15R)-Bimatoprost Acid D4 is a derivative of prostaglandin F2α, containing a 15-hydroxy group and an ethylamide residue at the 5-position. The deuterium atoms are present at specific positions in the molecule to aid in its identification during mass spectrometry. (15R)-Bimatoprost Acid D4 is typically administered as eye drops and has a half-life of about 45 minutes. It is metabolized primarily by the liver and excreted in the urine. The drug has demonstrated significant efficacy in reducing intraocular pressure and is well-tolerated by most patients. However, it may cause certain side effects such as ocular irritation, hyperemia, and changes in eyelash growth patterns.