Desacetyl Apremilast
| Product Name | Desacetyl Apremilast |
|---|---|
| Alternate Names | Apremilast Impurities, Impurities of Apremilast |
| CAT No. | CS-O-14905 |
| CAS No. | 635705-72-5 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 418.46 g/mol |
| Mol. For. | C₂₀H₂₂N₂O₆S |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Apremilast |
| Purity | >98% |
| Smileys | CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)N)OC |
| Canonical Smiles | CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)N)OC |
| InchIKey | BHJUWEUNUCJYER-OAHLLOKOSA-N |
| Inchl | InChI=1S/C20H22N2O6S/c1-4-28-17-10-12(8-9-16(17)27-2)15(11-29(3,25)26)22-19(23)13-6-5-7-14(21)18(13)20(22)24/h5-10,15H,4,11,21H2,1-3H3/t15-/m1/s1 |
| IUPAC | 4-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindole-1,3-dione |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Desacetyl Apremilast is a chemical compound that is commonly used in the pharmaceutical industry as an inhibitor of phosphodiesterase 4 (PDE4). This compound is a metabolite of Apremilast, a drug that is used in the treatment of various inflammatory diseases such as psoriasis, psoriatic arthritis, and Behcet's disease.
Desacetyl Apremilast is a white to off-white crystalline powder that is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and methanol. The chemical formula of Desacetyl Apremilast is C20H11N3O4, and its molecular weight is 369.32 g/mol.
The mechanism of action of Desacetyl Apremilast involves inhibition of the PDE4 enzyme, which is responsible for the breakdown of cyclic adenosine monophosphate (cAMP) in cells. By inhibiting PDE4, Desacetyl Apremilast increases intracellular levels of cAMP, which in turn leads to a reduction in the production of pro-inflammatory cytokines.
Desacetyl Apremilast has been shown to have anti-inflammatory and immunomodulatory effects in various preclinical models of inflammatory diseases. It has also been found to be effective in reducing the symptoms of psoriasis and psoriatic arthritis in clinical trials.
In conclusion, Desacetyl Apremilast is a potent inhibitor of PDE4 that has shown promise in the treatment of various inflammatory diseases. Its chemical properties and mechanism of action make it an important compound in the pharmaceutical industry.
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Related Compounds
Apremilast Dimer | Apremilast Impurity 77 | Apremilast Enantiomer | Desoxo Apremilast | Apremilast Dimer | Apremilast impurity D | Desacetyl Apremilast benzoic acid Impurity | Apremilast Desoxo impurity | Apremilast Impurity 2 | Diethoxy Rac-Apremilast Impurity | Apremilast Impurity 10 | Methyl Hydroxy Apremilast | Apremilast Impurity F | Apremilast 2-hydroxyethyl-sulfonyl impurity | Apremilast Impurity 18 | Apremilast Impurity 8 | Apremilast Impurity H | N-Desacetyl O4-Desmethyl Apremilast | N-Desacetyl O4-Desmethyl O3-Desethyl Apremilast | O4-Desmethyl O3-Desethyl Apremilast | Apremilast Impurity 17 | Apremilast Acetamido Sulfone Impurity | Apremilast Impurity B | Apremilast Isopropyl alcohol Impurity | Apremilast Degradation Impurity -2 | Apremilast pseudo dimer impurity | Apremilast Impurity C | Apremilast Impurity 15 |