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Desmethyl Amlodipine
| Chemical Name | Desmethyl Amlodipine |
|---|---|
| CAT No. | CS-O-14974 |
| CAS No. | 113994-37-9 |
| Status |
|
| Category | Impurities |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| Controlled | No |
Additional Information
| Packing | Product will be supplied in Vials, in certain conditions we also use 'Septa Vials' |
|---|---|
| Controlled | No |
| Parent API | Amlodipine |
| Therapeutic | Anti-Hypertensives |
| Smileys | O=C(C(C(C(C=CC=C1)=C1Cl)C(C(O)=O)=C(C)N2)=C2COCCN)OCC |
| Canonical Smiles | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)O)C)COCCN |
| InchIKey | RMMLXNROVBYURX-UHFFFAOYSA-N |
| Inchl | InChI=1S/C19H23ClN2O5/c1-3-27-19(25)17-14(10-26-9-8-21)22-11(2)15(18(23)24)16(17)12-6-4-5-7-13(12)20/h4-7,16,22H,3,8-10,21H2,1-2H3,(H,23,24) |
| IUPAC | 6-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-5-ethoxycarbonyl-2-methyl-1,4-dihydropyridine-3-carboxylic acid |
| Hazardous | No |
Usage and description
Desmethyl Amlodipine is a chemical compound that is used in the treatment of hypertension, angina, and other cardiovascular disorders. It is a metabolite of Amlodipine, which is a calcium channel blocker that works by relaxing the smooth muscles of the blood vessels, thereby reducing the pressure and increasing blood flow.
Desmethyl Amlodipine is a white crystalline powder that is soluble in water and organic solvents. It is structurally similar to Amlodipine, but it lacks the dihydropyridine ring structure that is present in Amlodipine. This makes Desmethyl Amlodipine less potent than Amlodipine, but it still has significant antihypertensive effects.
The chemical formula of Desmethyl Amlodipine is C20H25ClN2O5, and its molecular weight is 414.88 g/mol. It is metabolized in the liver and excreted in the urine. The half-life of Desmethyl Amlodipine is approximately 30 hours, which is longer than Amlodipine.
Desmethyl Amlodipine is usually administered orally in the form of tablets. The recommended dosage for adults is usually 2.5 to 10 mg per day, depending on the severity of the condition being treated. It should not be used in patients with severe hepatic impairment or hypotension. Common side effects of Desmethyl Amlodipine include dizziness, headache, flushing, and edema.
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