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Bilastine D6

Chemical Name Bilastine D6
CAT No. CS-O-15080
CAS Registry# 202189-78-4 (Unlabeled)
Status Prompt Dispatch
Category Stable Isotopes
Mol. Wt. 469.65 g/mol
Mol. For. C₂₈H₃₁D₆N₃O₃
Hazardous This is a Hazardous Compound
COA View Sample COA

Additional Information

Controlled No
Parent API Bilastine
Therapeutic Antihistamine
Smileys CCOCCN1C(C2CCN(CCC3=CC=C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O)=O)C=C3)CC2)=NC4=CC=CC=C14
Canonical Smiles CCOCCN1C2=CC=CC=C2N=C1C3CCN(CC3)CCC4=CC=C(C=C4)C(C)(C)C(=O)O
Inchl InChI=1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33)
IUPAC 2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid
Hazardous Yes

Usage and description

Bilastine D6 is a deuterated form of bilastine, which is a second-generation H1-receptor antagonist used for the treatment of allergic rhinitis and urticaria. Bilastine D6 is a stable isotope-labeled version of bilastine, which is commonly used in pharmacokinetic studies to evaluate the metabolism, distribution, and elimination of bilastine in the body. Chemically, bilastine D6 has the same molecular formula as bilastine, which is C28H37N3O3S. The only difference is that six hydrogen atoms in bilastine are replaced with deuterium atoms in bilastine D6. Deuterium is a non-radioactive isotope of hydrogen that has a higher atomic mass, which makes it useful for studying drug metabolism and pharmacokinetics. Bilastine D6 is typically administered orally in tablet form. It is rapidly absorbed in the gastrointestinal tract and reaches peak plasma concentrations within 1-1.5 hours after ingestion. Bilastine D6 undergoes extensive metabolism in the liver, primarily via cytochrome P450 enzymes, and is eliminated from the body mainly through urine and feces. In conclusion, Bilastine D6 is a helpful tool for researchers and clinicians to gain a better understanding of the pharmacokinetics and metabolism of bilastine, which can ultimately improve the treatment of allergic rhinitis and urticaria.

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