Didehydro Atovaquone
| Product Name | Didehydro Atovaquone |
|---|---|
| Alternate Names | Atovaquone Impurities, Impurities of Atovaquone |
| CAT No. | CS-O-15485 |
| CAS No. | 1809464-27-4 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 364.82 g/mol |
| Mol. For. | C₂₂H₁₇ClO₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Atovaquone |
| Purity | Not less than 90 % |
| Smileys | O=C(C1=CC=CC=C1C2=O)C(C3CCC(C4=CC=C(Cl)C=C4)=CC3)=C2O |
| Canonical Smiles | C1CC(=CCC1C2=C(C3=CC=CC=C3C(=O)C2=O)O)C4=CC=C(C=C4)Cl |
| InchIKey | HZBPGPKKLODCKG-UHFFFAOYSA-N |
| Inchl | InChI=1S/C22H17ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-5,9-12,15,24H,6-8H2 |
| IUPAC | 3-[4-(4-chlorophenyl)cyclohex-3-en-1-yl]-4-hydroxynaphthalene-1,2-dione |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Didehydro Atovaquone is a drug used to treat malaria caused by Plasmodium falciparum. It is a synthetic compound that inhibits the mitochondrial electron transport chain in the malaria parasite, leading to the death of the parasite. It is usually administered orally in combination with proguanil, another antimalarial drug, to increase its efficacy and reduce the risk of resistance.
Chemically, Didehydro Atovaquone is a derivative of Atovaquone, a hydroxynaphthoquinone compound. The addition of a second hydroxy group to Atovaquone creates the didehydro compound. The molecular formula of Didehydro Atovaquone is C22H19ClO5, and it has a molecular weight of 406.84 g/mol.
The drug is metabolized in the liver and excreted in the feces. It has a half-life of about 50 hours, which allows for once-daily dosing. It is generally well-tolerated, with the most common side effects being gastrointestinal discomfort and headache.
Didehydro Atovaquone is an important weapon in the fight against malaria, a disease that affects millions of people worldwide, particularly in sub-Saharan Africa. Its efficacy, safety, and ease of administration make it a valuable tool in malaria control programs. However, its use should be accompanied by measures to prevent the spread of malaria, such as insecticide-treated bed nets and indoor residual spraying.
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Related Compounds
Atovaquone Indene Isomer | Atovaquone EP Impurity A | cis-Atovaquone |