N-(4-chloro-2-((hydroxyimino)(phenyl)methyl)phenyl)-2-(methylamino)acetamide

N-(4-chloro-2-((hydroxyimino)(phenyl)methyl)phenyl)-2-(methylamino)acetamide is a chemical compound with the molecular formula C15H17ClN4O2. It is commonly referred to as CMH-1 and is categorized as a selective inhibitor of protein kinase R (PKR) autophosphorylation. The compound is primarily used in research studies to investigate the role of PKR in various biological processes. PKR is a serine/threonine kinase that plays an essential role in the interferon signaling pathway, which is involved in the immune response to viral infections. CMH-1 selectively inhibits the autophosphorylation of PKR, which has been shown to reduce cell death caused by viral infections and other stressors. The chemical structure of CMH-1 consists of a chloro-substituted phenyl ring, a hydroxyimino-phenylmethyl group, and a methylaminoacetamide group. The compound has a melting point of 210-212°C and is sparingly soluble in water, but soluble in organic solvents such as dimethyl sulfoxide (DMSO). Overall, N-(4-chloro-2-((hydroxyimino)(phenyl)methyl)phenyl)-2-(methylamino)acetamide is a valuable tool for researchers studying the role of PKR in various biological processes. Its selectivity and potency make it an excellent candidate for developing therapeutic interventions for viral infections and other diseases involving PKR dysregulation.