Sacubitril D4
| Product Name | Sacubitril D4 |
|---|---|
| Alternate Names | Sacubitril Stable Isotopes, Stable Isotopes of Sacubitril |
| CAT No. | CS-O-15672 |
| CAS No. | 1884269-07-1 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 415.52 g/mol |
| Mol. For. | C₂₄H₂₅D₄NO₅ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Sacubitril |
| Purity | >98 |
| Smileys | C[C@@H](C(OCC)=O)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |
| Canonical Smiles | CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O |
| InchIKey | PYNXFZCZUAOOQC-JCZLLWNUSA-N |
| Inchl | InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1/i13D2,14D2 |
| IUPAC | 2,2,3,3-tetradeuterio-4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Sacubitril D4, also known as LCZ696 D4, is a deuterated form of sacubitril, which is an angiotensin receptor-neprilysin inhibitor (ARNi) used in the treatment of heart failure. It is an orally administered medication that works by blocking the breakdown of natriuretic peptides, which are natural substances that help the body eliminate excess salt and water. By preventing their breakdown, sacubitril D4 helps to reduce fluid overload and improve heart function in patients with heart failure.
Chemically, sacubitril D4 is a white to off-white powder that has a molecular formula of C24H20D4N2O5 and a molecular weight of 440.53 g/mol. It is a deuterated analog of sacubitril, which means that several of the hydrogen atoms have been replaced with deuterium atoms. This modification can help to improve the pharmacokinetics and pharmacodynamics of the drug, leading to better efficacy and fewer side effects.
Sacubitril D4 is typically dosed at 200 mg once or twice daily, depending on the patient's condition and response to treatment. It is generally well-tolerated, although some patients may experience side effects such as hypotension, hyperkalemia, and renal impairment. As with any medication, it is important to follow the prescribed dosing regimen and to discuss any concerns or questions with a healthcare provider.
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Related Compounds
Sacubitril D4 Calcium Salt | Sacubitril 13C4 | Sacubitril metabolite LBQ657 13C4 | Sacubitril 13C4 Calcium | Sacubitrilat D4 | Sacubitrilat-13C4 |