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Sofosbuvir metabolite GS-566500 13CD3

Chemical Name Sofosbuvir metabolite GS-566500 13CD3
CAT No. CS-O-30478
CAS No. 1256490-46-6
Status Available for Immediate Dispatch
Category Stable Isotopes
Mol. Wt. 415.29 mol/g
Mol. For. C12(13C)H16D3FN3O9P
Hazardous This is not a Hazardous Compound
COA View Sample COA

Additional Information

Packing Product will be supplied in Vials, in certain conditions we also use 'Septa Vials'
Controlled No
Parent API Sofosbuvir
Purity 97.83
Therapeutic Antiretroviral / Anti-HIV
Smileys F[C@]1([C@H](N(C=CC2=O)C(N2)=O)O[C@H](CO[P](N[C@@H](C)C(O)=O)(O)=O)[C@H]1O)[13C]([2H])([2H])[2H]
Hazardous No

Usage and description

Sofosbuvir metabolite GS-566500 13CD3 is a stable isotopic labeled version of GS-566500, a metabolite of the antiviral drug Sofosbuvir. Sofosbuvir is a direct-acting antiviral medication used in the treatment of chronic hepatitis C virus (HCV) infection. The drug works by inhibiting the HCV RNA polymerase, which is essential for viral replication. GS-566500 is one of the major metabolites of Sofosbuvir, formed by the cytochrome P450 system in the liver. The stable isotopic labeled version of GS-566500, GS-566500 13CD3, is used in pharmacokinetic studies to assess the metabolism and elimination of Sofosbuvir in the body. This is done by administering a dose of Sofosbuvir to a patient and then monitoring the levels of GS-566500 and GS-566500 13CD3 in their blood or urine over time. The use of GS-566500 13CD3 allows for more accurate measurement of Sofosbuvir metabolism and elimination, which can help in determining optimal dosing regimens and predicting potential drug interactions. Chemically, GS-566500 13CD3 is a labeled version of GS-566500, with three deuterium atoms replacing three hydrogen atoms in the molecule. Deuterium is a stable, non-radioactive isotope of hydrogen that has a slightly higher mass, making it useful for tracking the metabolism of drugs in the body. Overall, the use of GS-566500 13CD3 is an important tool in the development and optimization of Sofosbuvir therapy for patients with HCV infection.

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