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Sofosbuvir metabolite GS-566500 13CD3
| Chemical Name | Sofosbuvir metabolite GS-566500 13CD3 |
|---|---|
| CAT No. | CS-O-30478 |
| CAS No. | 1256490-46-6 |
| Status | Available for Immediate Dispatch |
| Category | Stable Isotopes |
| Mol. Wt. | 415.29 mol/g |
| Mol. For. | C12(13C)H16D3FN3O9P |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
Additional Information
| Packing | Product will be supplied in Vials, in certain conditions we also use 'Septa Vials' |
|---|---|
| Controlled | No |
| Parent API | Sofosbuvir |
| Purity | 97.83 |
| Therapeutic | Antiretroviral / Anti-HIV |
| Smileys | F[C@]1([C@H](N(C=CC2=O)C(N2)=O)O[C@H](CO[P](N[C@@H](C)C(O)=O)(O)=O)[C@H]1O)[13C]([2H])([2H])[2H] |
| Hazardous | No |
Usage and description
Sofosbuvir metabolite GS-566500 13CD3 is a stable isotopic labeled version of GS-566500, a metabolite of the antiviral drug Sofosbuvir. Sofosbuvir is a direct-acting antiviral medication used in the treatment of chronic hepatitis C virus (HCV) infection. The drug works by inhibiting the HCV RNA polymerase, which is essential for viral replication. GS-566500 is one of the major metabolites of Sofosbuvir, formed by the cytochrome P450 system in the liver.
The stable isotopic labeled version of GS-566500, GS-566500 13CD3, is used in pharmacokinetic studies to assess the metabolism and elimination of Sofosbuvir in the body. This is done by administering a dose of Sofosbuvir to a patient and then monitoring the levels of GS-566500 and GS-566500 13CD3 in their blood or urine over time. The use of GS-566500 13CD3 allows for more accurate measurement of Sofosbuvir metabolism and elimination, which can help in determining optimal dosing regimens and predicting potential drug interactions.
Chemically, GS-566500 13CD3 is a labeled version of GS-566500, with three deuterium atoms replacing three hydrogen atoms in the molecule. Deuterium is a stable, non-radioactive isotope of hydrogen that has a slightly higher mass, making it useful for tracking the metabolism of drugs in the body. Overall, the use of GS-566500 13CD3 is an important tool in the development and optimization of Sofosbuvir therapy for patients with HCV infection.
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