Nadolol D9
| Product Name | Nadolol D9 |
|---|---|
| Alternate Names | Nadolol Stable Isotopes, Stable Isotopes of Nadolol |
| CAT No. | CS-O-30503 |
| CAS No. | 94513-92-5 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 318.46 g/mol |
| Mol. For. | C₁₇H₁₈D₉NO₄ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Nadolol |
| Purity | Not less than 90 % |
| Therapeutic | Anti-Migraines |
| Smileys | [2H]C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O |
| Canonical Smiles | CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O |
| InchIKey | VWPOSFSPZNDTMJ-PJODJJNBSA-N |
| Inchl | InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1/i1D3,2D3,3D3 |
| IUPAC | (2R,3S)-5-[3-[[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Nadolol D9 is a deuterated form of the beta-adrenergic blocker, nadolol. The deuterium substitution in Nadolol D9 involves the replacement of nine of the hydrogen atoms in the molecule with deuterium atoms. This isotopic substitution increases the molecular weight of Nadolol D9 and alters its chemical properties, resulting in a longer half-life and improved bioavailability.
Nadolol D9 is commonly used in the treatment of hypertension, angina, and arrhythmias. It works by blocking the action of epinephrine and norepinephrine, which are hormones that increase heart rate and blood pressure. By blocking these hormones, Nadolol D9 reduces heart rate and blood pressure, thereby decreasing the workload on the heart and improving cardiac function.
Chemically, Nadolol D9 is a white crystalline powder that is soluble in water and ethanol. Its chemical formula is C17H18D9NO4, and its molecular weight is 298.42 g/mol. The deuterium substitution in Nadolol D9 increases its mass by 9 atomic mass units, which can affect its metabolism and pharmacokinetics. The half-life of Nadolol D9 is approximately 24 hours, which is longer than the half-life of non-deuterated nadolol.
In conclusion, Nadolol D9 is an effective beta-adrenergic blocker that is used in the treatment of hypertension, angina, and arrhythmias. Its deuterium substitution improves its pharmacokinetics, resulting in a longer half-life and improved bioavailability.
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Related Compounds
iso-Nadolol (tert-Butyl-d9) (Mixture of Diastereomers) |