24-Epi-Calcipotriol
| Product Name | 24-Epi-Calcipotriol |
|---|---|
| Alternate Names | Calcipotriol Impurities, Impurities of Calcipotriol |
| CAT No. | CS-O-31161 |
| CAS No. | 112827-99-3 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 412.60 g/mol |
| Mol. For. | C₂₇H₄₀O₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Calcipotriol |
| Purity | 95% |
| Canonical Smiles | CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C |
| InchIKey | LWQQLNNNIPYSNX-CIJZWTHJSA-N |
| Inchl | InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25+,26+,27-/m1/s1 |
| IUPAC | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
24-Epi-Calcipotriol is a synthetic derivative of Vitamin D3 and acts as an analog of calcitriol. It is primarily used in the treatment of psoriasis, a chronic autoimmune skin disorder. The compound works by binding to Vitamin D receptors on skin cells, thereby regulating the growth and differentiation of these cells.
Research studies have shown that 24-Epi-Calcipotriol has similar efficacy to calcipotriol, a widely used topical medication for psoriasis. However, unlike calcipotriol, 24-Epi-Calcipotriol has a lower risk of inducing hypercalcemia, a condition characterized by elevated levels of calcium in the blood.
Chemically, 24-Epi-Calcipotriol is a highly lipophilic compound with a molecular weight of 412.68 g/mol. Its chemical formula is C27H40O3, and its systematic name is (1R,3S,5Z)-5-{2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene}-4-methylene-cyclohexane-1,3-diol.
In summary, 24-Epi-Calcipotriol is a promising therapeutic agent for the management of psoriasis due to its potent activity and low risk of adverse effects. However, further clinical trials are needed to establish its safety and efficacy in larger patient populations.
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Related Compounds
Calcipotriol EP Impurity H | BIS-TBDMS-TRANS-CALCIPOTRIOL | Calcipotriol EP Impurity I | Calcipotriol EP Impurity F | Calcipotriol EP Impurity G | Calcipotriol Impurity B | Alpha hydroxy Calcipotriol EP Impurity F | Calcipotriol Ethoxy Impurity | Calcipotriol EP Impurity E | pre-Calcipotriene 8-ene | Calcipotriol (Calcipotriene) beta-Isomer | Pre-Calcipotriol | Impurity of Calcipotriol | Racemic Calcipotriol Impurity B | Calcipotriol Impurity 9 | Calcipotriol EP Impurity A |