ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate

Ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate is a chemical compound with the molecular formula C15H13N3O6S. It is a yellow crystalline powder that is sparingly soluble in water but soluble in organic solvents. This compound is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It has shown potential as an anti-inflammatory agent and has been studied for its potential use in the treatment of cancer. The chemical structure of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate contains a thiazole ring, which is a five-membered heterocyclic ring containing both nitrogen and sulfur atoms. It also contains a nitro group, which is a functional group consisting of a nitrogen atom double-bonded to an oxygen atom and attached to an organic moiety. The hydroxyl group and the carboxylate group are both present in this compound, making it an acidic molecule. The synthesis of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate involves the reaction of 4-hydroxy-3-nitrobenzoic acid with methyl 2-aminothiazole-4-carboxylate in the presence of a coupling agent such as N,N'-dicyclohexylcarbodiimide (DCC). The resulting intermediate is then reacted with ethyl chloroformate to produce the final product. In conclusion, ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate is a versatile intermediate in the synthesis of many drugs and has shown potential as an anti-inflammatory agent and a potential treatment for cancer. Its chemical structure contains a thiazole ring, a nitro group, and both hydroxyl and carboxylate groups.