Bempedoic acid-D4

Bempedoic acid-D4 is a deuterated form of bempedoic acid, a medication used to lower cholesterol levels in patients with hypercholesterolemia. This drug works by inhibiting the enzyme ATP citrate lyase, which is responsible for the production of cholesterol in the liver. By blocking this enzyme, bempedoic acid-D4 reduces the amount of cholesterol produced by the liver, thereby lowering the levels of LDL (low-density lipoprotein) cholesterol in the blood. Bempedoic acid-D4 is administered orally, typically as a tablet. It should be taken once daily, either with or without food. The recommended dose is 180 mg per day, although dosage may vary depending on the patient's individual needs and response to treatment. Chemically, bempedoic acid-D4 is a derivative of bempedoic acid that has been labeled with four deuterium atoms. Deuterium is a heavy isotope of hydrogen that can be used in drug development to improve the pharmacokinetic properties of a drug. In the case of bempedoic acid-D4, the deuterium label helps to increase the drug's bioavailability and half-life, thereby improving its efficacy and reducing the frequency of dosing. Overall, bempedoic acid-D4 is a promising new medication for the treatment of hypercholesterolemia. Its unique mechanism of action and improved pharmacokinetic properties make it a valuable addition to the arsenal of drugs used to manage this common condition.