Varenicline Impurity 9(N-Nitroso varenicline)

Varenicline Impurity 9, also known as N-Nitroso varenicline, is a chemical compound that is used as an impurity in the production of the smoking cessation drug Varenicline. Varenicline is a prescription medication used to help people quit smoking. It works by binding to the same receptors in the brain that nicotine does, reducing the cravings and withdrawal symptoms associated with nicotine addiction. N-Nitroso varenicline is a byproduct of the synthesis of Varenicline and is present in small quantities as an impurity. It is important to monitor impurities in pharmaceuticals as they can affect the safety and efficacy of the drug. N-Nitroso varenicline is classified as a nitrosamine, a group of compounds that are known to be carcinogenic in humans. As a result, the presence of this impurity in Varenicline must be controlled to ensure that the drug is safe for use. In terms of chemical information, N-Nitroso varenicline has a molecular formula of C13H13N5O2 and a molecular weight of 279.28 g/mol. It is a yellow solid that is soluble in organic solvents. Its melting point is around 172-174°C. In conclusion, while N-Nitroso varenicline may be an impurity in Varenicline, it is important to monitor its presence as it can affect the safety of the drug. Understanding the chemical properties of N-Nitroso varenicline can aid in the development of strategies to control its presence in Varenicline.