(R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim
| Product Name | (R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim |
|---|---|
| Alternate Names | Ibrutinib Impurities, Impurities of Ibrutinib |
| CAT No. | CS-O-37342 |
| CAS No. | 1917333-91-5 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 494.5 g/mol |
| Mol. For. | C₂₈H₂₆N₆O₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Ibrutinib |
| Smileys | O=C(CC1)N=C2N1C=NC3=C2C(C4=CC=C(OC5=CC=CC=C5)C=C4)=NN3[C@H]6CN(C(C=C)=O)CCC6 |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
(R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim is a chemical compound that belongs to the class of pyrazolo[4,3-e]pyrimido[1,2-c]pyrimidines. It is a potent inhibitor of phosphodiesterase 5 (PDE5), which is an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. By inhibiting PDE5, this compound increases the concentration of cGMP, which leads to smooth muscle relaxation and increased blood flow to the penis, resulting in an erection.
This compound has potential therapeutic applications in the treatment of erectile dysfunction. It is highly selective for PDE5 and has a long half-life, which makes it a promising candidate for the treatment of this condition.
The chemical structure of this compound is characterized by a pyrazolo[4,3-e]pyrimido[1,2-c]pyrimidine core with an acryloylpiperidine moiety at position 8 and a phenoxyphenyl group at position 10. The stereochemistry of the acryloylpiperidine moiety is (R)-configuration.
In conclusion, (R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim is a potent and selective PDE5 inhibitor with potential therapeutic applications in the treatment of erectile dysfunction. Its unique chemical structure and high selectivity make it a promising candidate for further development as a treatment for this condition.
![Picture of (R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim](https://clearsynth.com/structure/-R--8--1-acryloylpiperidin-3-yl--10--4-phenoxyphenyl--3-4-dihydropyrazolo-4-3-e-pyrimido-1-2-c-pyrim.png)
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Related Compounds
Ibrutinib Dimer | Ibrutinib N-Oxide impurity | Ibrutinib Impurity 12 | Ibrutinib Impurity D | Ibrutinib impurity 25 | Ibrutinib Impurity 9 | Ibrutinib Hydroxy Impurity | Ibrutinib Michael addition adduct | Ibrutinib impurity Dimer | Ibrutinib Piperidine N-desacryl impurity | Ibrutinib N1-Oxide | N6-Acryloyl Ibrutinib | Ibrutinib Amino Piperidine dihydrochloride Impurity | Ibrutinib Impurity L | ibrutinib acetyl impurity | Rac -Ibrutinib propionaldehyde | N-Desacryloyl N-3-hydroxypropanoyl Ibrutinib | Ibrutinib Impurity 1 | Ibrutinib Impurity 15 | Ibrutinib Impurity 8 | Ibrutinib Impurity 6 | Ibrutinib Impurity 42 | Ibrutinib (IBR) Diamine Impurity | Ibrutinib Impurity 7 | Ibrutinib Di-piperidine impurity | N-Desacryloyl N-(3-Acryloyl-propanoyl) Ibrutinib | N1-(2-Carboxyethyl) Ibrutinib | Ibrutinib Piperidine impurity |