(4-dimethylamino-phenyl)-(4-dimethylamino-2-sulfomercapto-phenyl)-azamethinium-betaine

(4-dimethylamino-phenyl)-(4-dimethylamino-2-sulfomercapto-phenyl)-azamethinium-betaine, also known as DASB, is a fluorescent dye commonly used in biochemistry and medical research to study serotonin transporters (SERTs) in the brain. SERTs are proteins responsible for regulating the levels of serotonin, a neurotransmitter that affects mood, behavior, and other physiological processes. DASB is a selective SERT ligand that binds specifically to SERTs, allowing researchers to visualize and quantify their activity in live cells and tissues. DASB is a betaine-type dye that contains two dimethylamino groups, a phenyl ring, and a sulfomercapto group. Its chemical structure is similar to that of other SERT ligands such as fluoxetine and citalopram, which are commonly used antidepressant drugs. DASB is water-soluble and has a high quantum yield, making it an ideal fluorescent marker for in vitro and in vivo imaging studies. In addition to its applications in neuroscience research, DASB has also been used in other fields such as environmental monitoring and forensic science. Its sensitivity and selectivity for SERTs make it a valuable tool for detecting and quantifying trace amounts of serotonin and related compounds in complex biological and environmental samples. Overall, DASB is a versatile and important tool for studying the complex interactions between serotonin, SERTs, and other molecules in the brain and beyond. Its unique chemical properties and fluorescent capabilities make it a valuable asset for researchers in a wide range of scientific disciplines.