N-Nitroso-Atenolol

Chemical Name N-Nitroso-Atenolol
CAT No. CS-O-38043
CAS Registry# 134720-04-0
Category Impurities
Stock IN-Stock
Mol. Wt. 295.33 g/mol
Mol. For. C₁₄H₂₁N₃O₄
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Canonical Smiles CC(C)N(CC(COC1=CC=C(C=C1)CC(=O)N)O)N=O
InchIKey BLORPAGHSJJNFB-UHFFFAOYSA-N
Inchl InChI=1S/C14H21N3O4/c1-10(2)17(16-20)8-12(18)9-21-13-5-3-11(4-6-13)7-14(15)19/h3-6,10,12,18H,7-9H2,1-2H3,(H2,15,19)
IUPAC 2-[4-[2-hydroxy-3-[nitroso(propan-2-yl)amino]propoxy]phenyl]acetamide
Controlled No
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N-Nitroso-Atenolol is a chemical compound that is primarily used as a research tool in the study of cardiovascular diseases. It is a member of the nitrosoamines class of compounds, which have been identified as carcinogens in laboratory testing. N-Nitroso-Atenolol is formed when Atenolol, a beta blocker commonly used in the treatment of hypertension and cardiovascular disease, is exposed to nitrous acid. The chemical structure of N-Nitroso-Atenolol consists of a nitroso group (-NO) attached to the amine functional group of Atenolol. This modification alters the pharmacological properties of Atenolol, reducing its ability to block beta receptors in the heart and blood vessels. N-Nitroso-Atenolol has been shown to induce DNA damage and mutagenesis in laboratory studies, leading to concerns about its potential carcinogenicity. Despite its potential dangers, N-Nitroso-Atenolol remains an important tool for researchers investigating the mechanisms of cardiovascular disease. By studying the effects of this compound on cells and tissues, scientists can gain a better understanding of the pathways involved in the development and progression of heart disease. However, due to its potential hazards, strict safety protocols must be followed when handling N-Nitroso-Atenolol in the laboratory.

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