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8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine, also known as CL-218,872, is a mixture of isomers that belongs to the class of benzodiazepines. It is primarily used as a research chemical and is not approved for clinical use.
CL-218,872 acts as a selective antagonist of the benzodiazepine site on the GABA-A receptor. This receptor is a type of protein found in the central nervous system that modulates the activity of the neurotransmitter gamma-aminobutyric acid (GABA). By blocking the binding of benzodiazepines to this receptor, CL-218,872 can interfere with the sedative and anxiolytic effects of these drugs.
In addition to its use in research, CL-218,872 can be used as a reference standard in forensic toxicology to detect the presence of benzodiazepines in biological samples. Its chemical formula is C22H21ClN6O2 and its molecular weight is 438.9 g/mol. It has a melting point of 214-216°C and is soluble in organic solvents such as methanol and DMSO.
Overall, CL-218,872 is a potent and selective antagonist of the GABA-A receptor benzodiazepine site that has applications in research and forensic toxicology. Its chemical structure and properties make it a useful tool for investigating the role of benzodiazepines in the brain and detecting their presence in biological samples.
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