(S)-Cinacalcet-D3

(S)-Cinacalcet-D3 is a deuterated analog of the drug Cinacalcet, which is used for the treatment of hyperparathyroidism and hypercalcemia in patients with chronic kidney disease. The deuterated form of the drug, (S)-Cinacalcet-D3, is used in research and development to study the pharmacokinetics and metabolism of Cinacalcet. The mechanism of action of Cinacalcet and its deuterated analog involves binding to the calcium-sensing receptor (CaSR) on the parathyroid gland, which suppresses the secretion of parathyroid hormone (PTH). This leads to a decrease in the levels of calcium in the blood, which is beneficial for patients with hyperparathyroidism and hypercalcemia. The chemical formula of (S)-Cinacalcet-D3 is C22H22D3F3N, and it has a molecular weight of 351.42 g/mol. The drug is administered orally, with a recommended dosage of 30-180 mg per day. (S)-Cinacalcet-D3 is metabolized by the liver, primarily through the cytochrome P450 system. The drug has a half-life of approximately 30 hours and is excreted in the urine and feces. (S)-Cinacalcet-D3 is an important tool in the study of the pharmacokinetics and metabolism of Cinacalcet. Its deuterated form allows for more accurate measurements of the drug's distribution, elimination, and bioavailability in the body.