N-Nitroso N-Desmethyl-Chlorpheniramine

N-Nitroso N-Desmethyl-Chlorpheniramine (NDMA-CPA) is a chemical compound that is commonly used as an antihistamine medication for the treatment of allergies and hay fever. It is a derivative of chlorpheniramine, which is a first-generation antihistamine that is known for its sedative effects. NDMA-CPA is a potent histamine H1 receptor antagonist, which means it blocks the effects of histamine in the body and prevents allergic reactions. NDMA-CPA is also used in the laboratory as a carcinogenic agent. This is because it is a nitrosamine, a class of chemicals that has been shown to cause cancer in animals and is suspected to be carcinogenic to humans. Nitrosamines are formed by the reaction of nitrites with secondary amines, including NDMA-CPA. The chemical structure of NDMA-CPA consists of a phenyl ring, a chloro group, and a dimethylamino group attached to a nitrogen atom. The nitroso group (NO) is also attached to the nitrogen atom. The compound has a molecular weight of 305.8 g/mol and a melting point of 180-182°C. In conclusion, NDMA-CPA is a potent antihistamine medication that is commonly used for the treatment of allergies and hay fever. However, it is also a carcinogenic agent that is used in laboratory experiments. Its chemical structure consists of a phenyl ring, a chloro group, a dimethylamino group, and a nitroso group attached to a nitrogen atom.