N-Nitroso-N-Desmethyl-Clarithromycin

N-Nitroso-N-Desmethyl-Clarithromycin (NDMC) is a derivative of the antibiotic Clarithromycin, which is commonly used to treat bacterial infections. NDMC is a nitrosated metabolite of Clarithromycin and has been found to exhibit potent anti-tumor activity. NDMC is known to act as a DNA alkylating agent, causing damage to DNA by adding alkyl groups to the nitrogen atoms in the DNA bases. This results in DNA strand breaks and ultimately leads to cell death. NDMC has also been found to inhibit the growth of various cancer cell lines, including leukemia, breast, lung, and colon cancer cells. Despite its potential therapeutic benefits, NDMC is considered to be a carcinogen due to its ability to induce tumors in animal models. Therefore, its use in humans is limited and requires careful consideration. In conclusion, NDMC is a potent anti-tumor agent that exhibits DNA alkylating properties. However, due to its carcinogenic potential, its use in humans is limited and requires thorough evaluation of the risks and benefits before administration.