Nevirapine D8

Nevirapine D8, also known as (6R, trans)-6-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydro-4-(1-methylethyl)-2,3-dioxopyrimidine-5-carboxamide-d8, is a deuterium-labeled version of the antiretroviral drug Nevirapine. Nevirapine D8 is commonly used in pharmacokinetic studies to determine the metabolism and elimination of Nevirapine in the body. The deuterium labeling allows for precise measurements of drug concentrations in blood and other bodily fluids, providing valuable information for dosing and drug interactions. Nevirapine D8 works by inhibiting the reverse transcriptase enzyme, which is responsible for the replication of the human immunodeficiency virus (HIV) that causes acquired immunodeficiency syndrome (AIDS). By blocking the replication of the virus, Nevirapine D8 helps to slow the progression of HIV and improve the immune system function in those infected with the virus. The chemical formula of Nevirapine D8 is C15H10D8N4O, with a molecular weight of 277.36 g/mol. It is a white to off-white powder that is soluble in water and ethanol. Like its unlabeled counterpart, Nevirapine D8 may cause side effects such as rash, fever, nausea, and liver toxicity. It is important to consult with a healthcare professional before taking this medication. Overall, Nevirapine D8 is a valuable tool in the study and treatment of HIV/AIDS.