N7-Nitroso Theophylline

1,3-Dimethyl-7-nitroso-3,7-dihydro-1H-purine-2,6-dione is a chemical compound with the molecular formula C8H7N5O4. It is a yellow crystalline powder that is sparingly soluble in water and has a melting point of 290-292 °C. This compound has been found to possess various biological activities and has been investigated for its potential therapeutic applications. One of the most significant uses of 1,3-Dimethyl-7-nitroso-3,7-dihydro-1H-purine-2,6-dione is as an inhibitor of cyclic nucleotide phosphodiesterase (PDE). This enzyme is involved in the degradation of cyclic AMP (cAMP) and cyclic GMP (cGMP), which are important second messengers in various signaling pathways. Inhibition of PDE by this compound results in an increase in the levels of cAMP and cGMP, which can lead to a range of physiological effects such as smooth muscle relaxation, vasodilation, and inhibition of platelet aggregation. As such, this compound has been investigated for its potential use in the treatment of various cardiovascular and respiratory disorders. In addition to its PDE-inhibitory activity, 1,3-Dimethyl-7-nitroso-3,7-dihydro-1H-purine-2,6-dione has also been found to possess antimicrobial and antitumor properties. It has been shown to inhibit the growth of various bacterial and fungal strains and has also demonstrated selective cytotoxicity towards certain cancer cell lines. The precise mechanisms underlying these activities are not fully understood, but it is believed that they may be mediated by the compound's ability to generate reactive oxygen species and to interfere with DNA synthesis and repair. Overall, 1,3-Dimethyl-7-nitroso-3,7-dihydro-1H-purine-2,6-dione is a promising compound with a range of potential therapeutic applications. However, more research is needed to fully elucidate its mechanisms of action and to assess its safety and efficacy in vivo.