N,N′-Dimethylethylenedinitrosamine
| Product Name | N,N′-Dimethylethylenedinitrosamine |
|---|---|
| Alternate Names | Clonidine Nitrosamine, Nitrosamine of Clonidine |
| CAT No. | CS-O-41454 |
| CAS No. | 13256-12-7 |
| Category | Nitrosamine |
| Stock | IN-Stock |
| Mol. Wt. | 146.20 g/mol |
| Mol. For. | C₄H₁₀N₄O₂ |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Clonidine |
| Canonical Smiles | CN(CCN(C)N=O)N=O |
| InchIKey | YHIARNFLMZPJGR-UHFFFAOYSA-N |
| Inchl | InChI=1S/C4H10N4O2/c1-7(5-9)3-4-8(2)6-10/h3-4H2,1-2H3 |
| IUPAC | N-methyl-N-[2-[methyl(nitroso)amino]ethyl]nitrous amide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Clonidine is a central alpha agonist drug commonly used to treat hypertension, attention deficit hyperactivity disorder (ADHD), and certain types of pain. However, the drug can contain an impurity known as diethylamine dinitroso (DEDN), which is a potential human carcinogen and mutagen.
DEDN is a yellow, crystalline solid that is highly reactive and unstable. It is formed during the synthesis of clonidine when diethylamine reacts with nitrous acid. DEDN is classified as a nitrosamine, which is a type of chemical compound that can cause cancer in humans.
The presence of DEDN in clonidine can have serious health consequences for patients. Long-term exposure to DEDN has been linked to an increased risk of bladder cancer, liver cancer, and leukemia. The World Health Organization (WHO) has classified DEDN as a Group 2A carcinogen, which means that it is probably carcinogenic to humans.
To prevent the harmful effects of DEDN, pharmaceutical companies must closely monitor the manufacturing process of clonidine and ensure that DEDN levels do not exceed acceptable limits. Patients who are prescribed clonidine should also be aware of the potential risks associated with DEDN and discuss any concerns with their healthcare provider.
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