N-desmethyl N-Nitroso Topotecan-D3

N-desmethyl N-Nitroso Topotecan-D3 is a stable isotopic labeled analog of the anticancer drug, Topotecan. It is used as a reference standard in clinical and biomedical research to investigate the metabolic fate and pharmacokinetics of Topotecan. Topotecan is a topoisomerase inhibitor that is used to treat various types of cancers such as ovarian, lung, and cervical cancer. The drug works by inhibiting the DNA replication process in cancer cells, which leads to cell death. N-desmethyl N-Nitroso Topotecan-D3 has a molecular formula of C23H21D3N4O6 and a molecular weight of 469.5 g/mol. The compound is prepared by the chemical synthesis of Topotecan-D3, which involves the use of deuterated reagents. The compound is a yellowish-orange powder that is soluble in organic solvents such as methanol and acetonitrile. The chemical structure of N-desmethyl N-Nitroso Topotecan-D3 consists of a lactone ring, a pyrrolidine ring, and a nitroso group. The deuterium atoms in the molecule make it suitable for use in drug metabolism studies, as they can be differentiated from the non-labeled Topotecan. The compound is stable under normal laboratory conditions and can be stored for extended periods without significant degradation. In conclusion, N-desmethyl N-Nitroso Topotecan-D3 is a useful tool in cancer research, particularly in investigating the pharmacokinetics and metabolism of Topotecan. Its stable isotopic labeling and chemical properties make it a reliable reference standard for researchers in the field.