2-deoxy-D-glucose-6-phosphate, disodium salt

2-deoxy-D-glucose-6-phosphate, disodium salt (2-DG-6P) is a synthetic molecule that is commonly used in biochemical research. It is a phosphorylated form of the simple sugar 2-deoxy-D-glucose (2-DG), which is structurally similar to glucose but lacks a hydroxyl group at the 2 position. This makes it a competitive inhibitor of glucose metabolism and an effective tool for studying cellular metabolism. In particular, 2-DG-6P is often used in studies of the glycolytic pathway, which is the primary metabolic pathway used by cells to generate energy. By inhibiting the activity of enzymes involved in glycolysis, 2-DG-6P can alter cellular metabolism and provide insights into the regulation of this pathway. Additionally, 2-DG-6P can be used to label or selectively inhibit specific enzymes or pathways within the glycolytic pathway, allowing for more targeted studies. From a chemical standpoint, 2-DG-6P is a disodium salt of the phosphorylated form of 2-DG. Its molecular formula is C6H11Na2O9P, and it has a molecular weight of 308.1 g/mol. It is typically supplied as a white to off-white powder that is soluble in water and other polar solvents. While 2-DG-6P is generally considered safe for use in research, it should be handled with care and disposed of properly according to laboratory safety protocols.