2-deoxy-D-[UL-13C6]glucose-6-phosphate disodium salt

2-deoxy-D-[UL-13C6]glucose-6-phosphate disodium salt, also known as 2DG-6P, is a stable isotopically labeled derivative of glucose. It is a compound commonly used in biochemical and metabolic studies, particularly in the field of cancer research. 2DG-6P is a phosphorylated form of 2-deoxyglucose, which is a glucose analog that can be taken up by cells but cannot be metabolized in the same way as glucose. This makes it a useful tool for studying glucose metabolism, as it can be used to selectively inhibit glycolysis, a process that is often upregulated in rapidly dividing cancer cells. The incorporation of 13C into the molecule allows for the tracking of the compound through metabolic pathways and provides a more detailed understanding of glucose metabolism in cells. It can be detected using techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. 2DG-6P has also been used as a potential treatment for cancer, as it has been shown to sensitize cancer cells to radiation therapy and chemotherapy. This is thought to be due to its ability to interfere with the energy production pathways of cancer cells. Overall, 2DG-6P is a valuable tool for studying glucose metabolism and has potential applications in cancer treatment. Its stable isotopic labeling allows for precise tracking of the compound through metabolic pathways, providing valuable insights into cellular metabolism.