3-deoxy-3-fluoro-D-glucose

3-deoxy-3-fluoro-D-glucose (3FDG) is a synthetic glucose analog that has been used extensively in medical imaging studies as a radiotracer. This compound is structurally similar to glucose, with the exception that the hydroxyl group at the C-3 position has been replaced with a fluorine atom. This modification allows for the compound to be detected by positron emission tomography (PET) imaging techniques. In PET imaging, 3FDG is administered to the patient intravenously and it travels through the bloodstream to cells that are actively using glucose, such as cancer cells. The compound is taken up by cells and metabolized similarly to glucose, with the exception that it cannot be fully metabolized, leading to an accumulation of the compound in the cells. The accumulation of 3FDG in cells allows for the detection of areas of high glucose metabolism, which is often indicative of cancerous tissue. Chemically, 3FDG is a white to off-white powder that is soluble in water. It has a molecular weight of 182.14 g/mol and a melting point of 142-147°C. The compound is stable under normal conditions and can be stored at room temperature for extended periods of time. In conclusion, 3-deoxy-3-fluoro-D-glucose is a useful radiotracer for medical imaging studies, particularly in the detection of cancerous tissue. Its chemical properties allow for easy administration and detection, making it a valuable tool in the fight against cancer.