2-deoxy-D-[1-D]glucose

2-deoxy-D-[1-D]glucose, also known as 2-DG, is a glucose analogue that is structurally similar to glucose, but lacks the hydroxyl group at the 2-position. This structural difference results in the compound being unable to undergo glycolysis, which is the process by which glucose is converted into energy in cells. 2-DG has been studied for its potential therapeutic use in cancer treatment. Cancer cells have a higher glucose uptake rate than normal cells and by inhibiting glycolysis, 2-DG can selectively target cancer cells without affecting normal cells. This mechanism has been shown to enhance the efficacy of chemotherapy and radiation therapy in preclinical studies. Additionally, 2-DG has been studied for its potential use in treating neurological disorders such as Alzheimer's disease. The compound has been shown to reduce the accumulation of amyloid beta plaques, which are a hallmark of the disease, in the brains of mice. In terms of chemical information, 2-DG has a molecular formula of C6H12O5 and a molecular weight of 164.16 g/mol. It is soluble in water and has a melting point of 146-148°C. The compound is typically administered via injection or orally as a pill. However, further research is needed to fully understand the potential benefits and side effects of 2-DG in humans.