Ketoconazole Impurity D

Product Name Ketoconazole Impurity D
Alternate Names Ketoconazole Impurities, Impurities of Ketoconazole
CAT No. CS-P-00436
CAS No. 67914-61-8
Category Impurities
Stock IN-Stock
Mol. Wt. 489.39 g/mol
Mol. For. C₂₄H₂₆Cl₂N₄O₃
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Ketoconazole
Purity 95%
Therapeutic Anti-Fungals
Smileys C1CN(CCN1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
Canonical Smiles C1CN(CCN1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
InchIKey LOUXSEJZCPKWAX-URXFXBBRSA-N
Inchl InChI=1S/C24H26Cl2N4O3/c25-18-1-6-22(23(26)13-18)24(16-29-10-7-28-17-29)32-15-21(33-24)14-31-20-4-2-19(3-5-20)30-11-8-27-9-12-30/h1-7,10,13,17,21,27H,8-9,11-12,14-16H2/t21-,24-/m0/s1
IUPAC 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
Controlled No
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Ketoconazole Impurity D is a chemical intermediate that is commonly used in the synthesis of Ketoconazole, a powerful antifungal medication. It is a crystalline powder that has a molecular weight of 289.39 g/mol and a melting point of approximately 130-132°C. Its chemical formula is C14H10Cl2N2O. The primary usage of Ketoconazole Impurity D is in the pharmaceutical industry, where it is used as a starting material for the production of Ketoconazole. The impurity is typically produced through the oxidation of the intermediate compound, which is then further processed to form the final product. Chemically, Ketoconazole Impurity D is a derivative of imidazole and contains two chlorine atoms attached to the benzene ring. It is a potent inhibitor of cytochrome P450 enzymes, which are responsible for the metabolism of many drugs in the liver. This property makes it a valuable intermediate in the production of Ketoconazole, as it enhances the effectiveness of the medication by preventing the breakdown of the drug in the liver. In conclusion, Ketoconazole Impurity D is an essential chemical intermediate that is widely used in the pharmaceutical industry for the production of Ketoconazole. Its unique chemical properties make it a valuable starting material for the synthesis of the medication, which is used to treat a variety of fungal infections.

Related Compounds

Cis-tosylate Ketoconazole | N-Nitroso Ketoconazole Impurity D | Ketoconazole Impurity C | Levoketoconazole | Ketoconazole impurity 1 | N-Acetylpiperazine-N'-(4-phenol) Ketoconazole | Ketoconazole Hydroxy Impurity | Ketoconazole Impurity 25 | Ketoconazole Impurity 3 | Ketoconazole Impurity 7 | DextroKetoconazole | Ketoconazole Impurity E |

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