Nitazoxanide Impurity 1

Product Name Nitazoxanide Impurity 1
Alternate Names Nitazoxanide Impurities, Impurities of Nitazoxanide
CAT No. CS-P-01179
CAS No. 402848-76-4
Category Impurities
Stock IN-Stock
Mol. Wt. 262.28 g/mol
Mol. For. C₁₂H₁₀N₂O₃S
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Nitazoxanide
Therapeutic Antiretroviral / Anti-HIV
Smileys CC(OC1=CC=CC=C1C(NC2=NC=CS2)=O)=O
Canonical Smiles CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=CS2
InchIKey GXWWYCHNNUHFAL-UHFFFAOYSA-N
Inchl InChI=1S/C12H10N2O3S/c1-8(15)17-10-5-3-2-4-9(10)11(16)14-12-13-6-7-18-12/h2-7H,1H3,(H,13,14,16)
IUPAC [2-(1,3-thiazol-2-ylcarbamoyl)phenyl] acetate
Controlled No
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Nitazoxanide Impurity 1, also known as 2-Amino-5-nitrothiazole, is an impurity that is commonly found in Nitazoxanide drug substances. Nitazoxanide is an antiprotozoal and antihelmintic medication used to treat a variety of infections caused by parasites such as Giardia lamblia, Cryptosporidium parvum, Entamoeba histolytica, and Hymenolepis nana. Nitazoxanide Impurity 1 is formed during the manufacturing process of Nitazoxanide and is considered a degradation product. The chemical formula for Nitazoxanide Impurity 1 is C3H3N3O2S, and its molecular weight is 153.14 g/mol. It is a yellow crystalline powder that is sparingly soluble in water but soluble in organic solvents such as methanol and ethanol. Nitazoxanide Impurity 1 is a nitrothiazole derivative that contains an amino group, and it is mainly used as a reference standard for analytical purposes. Nitazoxanide Impurity 1 can affect the quality of Nitazoxanide drug products, and its presence must be monitored and controlled during the manufacturing process to ensure the purity of the final drug substance. Its concentration in the drug substance should be limited to a maximum of 0.1% w/w, as per the International Council for Harmonisation (ICH) guidelines. Nitazoxanide Impurity 1 is also used as a reference standard for the development and validation of analytical methods used in the quality control of Nitazoxanide drug products.

Related Compounds

N-Nitroso Nitazoxanide | Nitazoxanide Impurity 2 |

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