(2S, 4S)-Sacubitril-d4
| Product Name | (2S, 4S)-Sacubitril-d4 |
|---|---|
| Alternate Names | Sacubitril Stable Isotopes, Stable Isotopes of Sacubitril |
| CAT No. | CS-P-02624 |
| CAS No. | 149709-63-7(Unlabeled) |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Sacubitril |
| Smileys | C[C@H](C(OCC)=O)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |
| Canonical Smiles | CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O |
| InchIKey | PYNXFZCZUAOOQC-UWJYYQICSA-N |
| Inchl | InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21-/m0/s1 |
| IUPAC | 4-[[(2S,4S)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
(2S, 4S)-Sacubitril-d4 is a deuterated form of Sacubitril. It is a medication used for the treatment of heart failure. This medication is a prodrug that is converted into the active form, Sacubitrilat, via the enzyme neprilysin. Sacubitrilat works by inhibiting neprilysin, an enzyme that degrades natriuretic peptides, which are hormones that help regulate blood pressure and fluid balance in the body. This leads to an increase in the levels of natriuretic peptides, resulting in vasodilation and diuresis, which help improve heart failure symptoms.
The chemical formula of (2S, 4S)-Sacubitril-d4 is C24H28D4N2O5. It has a molecular weight of 448.57 g/mol. The deuterium atoms in the compound are stable isotopes of hydrogen that can be used for tracking purposes in pharmacokinetic studies.
The recommended dosage of (2S, 4S)-Sacubitril-d4 is 97 mg twice daily, taken orally. This medication is generally well-tolerated, but common side effects include hypotension, hyperkalemia, and cough. Patients with a history of angioedema or who are taking ACE inhibitors should not take (2S, 4S)-Sacubitril-d4.
In conclusion, (2S, 4S)-Sacubitril-d4 is an important medication used for the treatment of heart failure. Its chemical properties make it useful for tracking purposes in pharmacokinetic studies. While it is generally well-tolerated, patients should be aware of potential side effects and consult with their healthcare provider before taking this medication.
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Related Compounds
Sacubitril 13C4 | Sacubitril 13C4 Calcium | Sacubitrilat-13C4 | Sacubitril metabolite LBQ657 13C4 | Sacubitril D4 | Sacubitril D4 Calcium Salt | Sacubitrilat D4 |