18-Methoxycoronaridine-d4

18-Methoxycoronaridine-d4 (18-MC-d4) is a deuterated analog of 18-Methoxycoronaridine (18-MC), which is a naturally occurring iboga alkaloid derived from the roots of the African shrub Tabernanthe iboga. 18-MC-d4 is a selective antagonist of the α3β4 nicotinic acetylcholine receptor, which plays a key role in addiction and drug-seeking behavior. Studies have shown that 18-MC-d4 has potential therapeutic applications in the treatment of drug addiction, particularly for opioid addiction. It has been found to reduce drug-seeking behavior in animal models of addiction, and has also been shown to alleviate withdrawal symptoms in opioid-dependent rats. Chemically, 18-MC-d4 is a labeled compound, meaning that it contains four deuterium atoms in place of four hydrogen atoms. This isotopic substitution is useful in pharmacological research, as it allows for the tracking of the compound in biological systems using mass spectrometry. In summary, 18-MC-d4 is a promising compound for the treatment of drug addiction, particularly for opioid addiction. Its selective antagonism of the α3β4 nicotinic acetylcholine receptor makes it a potentially effective tool in reducing drug-seeking behavior and alleviating withdrawal symptoms. Its labeled nature also makes it useful in pharmacological research.