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21-Desisobutyryl Ciclesonide-D11

Chemical Name 21-Desisobutyryl Ciclesonide-D11
CAT No. CS-P-02772
CAS Registry# 161115-59-9(Unlabeled)
Status Under Certification (Usually dispatched in 5 days)
Category Stable Isotopes
Hazardous This is not a Hazardous Compound
COA View Sample COA
Controlled No

Additional Information


Controlled No
Parent API Ciclesonide
Therapeutic Anti-Asthma / COPD
Smileys O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C5)(O[C@H](C6([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C6([2H])[2H])O1)[C@]25C)CO
Canonical Smiles CC12CC(C3C(C1CC4C2(OC(O4)C5CCCCC5)C(=O)CO)CCC6=CC(=O)C=CC36C)O
InchIKey OXPLANUPKBHPMS-ZXBNPROVSA-N
Inchl InChI=1S/C28H38O6/c1-26-11-10-18(30)12-17(26)8-9-19-20-13-23-28(22(32)15-29,27(20,2)14-21(31)24(19)26)34-25(33-23)16-6-4-3-5-7-16/h10-12,16,19-21,23-25,29,31H,3-9,13-15H2,1-2H3/t19-,20-,21-,23+,24+,25+,26-,27-,28+/m0/s1
IUPAC (1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Hazardous No


Usage and description


21-Desisobutyryl Ciclesonide-D11 is a synthetic glucocorticoid and a deuterated analog of the active pharmaceutical ingredient ciclesonide used in the treatment of asthma and allergic rhinitis. It is a stable isotopic labeled compound that is used in clinical research and drug development studies to evaluate the pharmacokinetics and pharmacodynamics of ciclesonide. The chemical formula of 21-Desisobutyryl Ciclesonide-D11 is C24H26D11ClO6 and its molecular weight is 514.09 g/mol. The compound is a white to off-white powder that is sparingly soluble in water, freely soluble in methanol, and soluble in acetone and ethanol. The mechanism of action of 21-Desisobutyryl Ciclesonide-D11 involves binding to the glucocorticoid receptor and regulating the expression of various inflammatory genes. This leads to a reduction in the production of pro-inflammatory cytokines and chemokines, thereby suppressing the immune response and alleviating the symptoms of asthma and allergic rhinitis. In terms of usage, 21-Desisobutyryl Ciclesonide-D11 is primarily used in preclinical and clinical studies to evaluate the bioavailability, metabolism, and excretion of ciclesonide in humans. It is also used in the development of new drug formulations and dosage forms of ciclesonide, as well as in the optimization of therapeutic regimens for the treatment of asthma and allergic rhinitis.

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