5-Fluorouracil-13C 15N2
| Product Name | 5-Fluorouracil-13C 15N2 |
|---|---|
| Alternate Names | Fluorouracil Stable Isotopes, Stable Isotopes of Fluorouracil |
| CAT No. | CS-P-02912 |
| CAS No. | 1189423-58-2 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 133.06 g/mol |
| Mol. For. | C₃¹³CH₃F¹⁵N₂O₂ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Fluorouracil |
| Purity | Not less than 90 % |
| Therapeutic | Immunosuppressants |
| Smileys | O=C([15NH]1)C(F)=C[15NH][13C]1=O |
| Canonical Smiles | C1C(C(=O)NC(=O)N1)F |
| InchIKey | RAIRJKWTBBDDAR-XZQGXACKSA-N |
| Inchl | InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9)/i4+1,6+1,7+1 |
| IUPAC | 5-fluoro-(213C,1,3-15N2)1,3-diazinane-2,4-dione |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
5-Fluorouracil-13C 15N2 is a modified version of the chemotherapy drug 5-Fluorouracil (5-FU). The addition of 13C and 15N isotopes to the molecule allows for the tracking of the drug's distribution and metabolism in the body using nuclear magnetic resonance (NMR) spectroscopy.
5-FU is commonly used in the treatment of several types of cancer, including breast, colon, and stomach cancer. It works by inhibiting the growth of cancer cells by interfering with the production of DNA and RNA. The modified version, 5-Fluorouracil-13C 15N2, can help researchers better understand how the drug is metabolized and distributed in the body, which can lead to improvements in treatment efficacy and reduced side effects.
Chemically, 5-Fluorouracil-13C 15N2 is a pyrimidine analog that is converted to 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) in the body. FdUMP inhibits the activity of thymidylate synthase, an enzyme that is necessary for the production of thymidine, a building block of DNA. This ultimately leads to the inhibition of DNA synthesis and cell division in cancer cells.
In conclusion, 5-Fluorouracil-13C 15N2 is a modified version of the chemotherapy drug 5-FU that allows for better tracking of the drug's distribution and metabolism in the body. Its use can lead to improved treatment efficacy and reduced side effects for cancer patients.
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